
Insomnia is a common sleep disorder characterized by difficulties falling asleep, staying asleep, or both. It can be acute or chronic depending on its duration. That said, acute insomnia, also known as short-term insomnia, lasts for a few days or weeks and is often caused by stress or a stressful event. Chronic or long-term insomnia, on the other hand, occurs at least three times a week for at least three months.
In addition, about 80% of adults experience or will experience acute insomnia at some point in their lives, whereas 14% of the general adult population suffers from chronic insomnia. And, when it comes to treatment, acute insomnia typically goes away on its own. Still, chronic insomnia requires medical treatment, especially when sleep hygiene, lifestyle changes, and cognitive behavioral therapy (CBT) don’t provide relief.
Medications used for treating insomnia might include:
- Hypnotics
- Sedatives
- Medications that cause sedation as a side effect
- Medications directed at the circadian neuroendocrine system
- Medications used in treating insomnia-inducing sleep diagnoses
The Role of Medications in Treating Insomnia
The only medications that have proven their effectiveness when it comes to treating chronic insomnia are the latest GABA-effective hypnotics. Most of the evidence supports the efficacy of CBT and short-acting GABA-receptor agonists.
Furthermore, people with comorbid insomnia who use hypnotics can experience improved outcomes and potentially reduced morbidity and mortality, typically linked with the use of other, more toxic medications.
In those who have developed insomnia due to circadian disturbance, mood disorders like depression, or other sleep disorders like restless leg syndrome, the evidence supporting other medications’ efficacy is minimal, regardless of the widespread use.
Moreover, medications used off-label for sedative side effects and sedatives are a major factor contributing to drug-induced hypersomnolence, i.e., excessive sleepiness, which contributes to more than 30% of deaths caused by motor accidents.
On the other hand, insomnia patients who have reduced quality of life and daily function can significantly and safely benefit from hypnotic medications with low toxicity and addictive potential, as well as minimal hypersomnolence.
Other medications that produce sedation should be used carefully due to the increased risk of accidents as a result of drug-induced sleepiness, and their toxicities and negative side effects, too.
Insomnia Linked with Sleep Apnea and Its Treatment
Obstructive sleep apnea (OSA) is another common sleep disorder affecting millions of people characterized by frequent breathing pauses during sleep.
OSA results in extreme daytime sleepiness in the majority of patients, affecting daily function and quality of life. Unfortunately, OSA severity and daytime hypersomnolence can be exacerbated by the use of sedatives, especially opiates and ethanol.
Additionally, in a part of OSA patients, disrupted breathing can lead to disordered sleep and insomnia. In this case, the go-to OSA treatment that involves special sleep equipment that utilizes positive airway pressure can improve sleep quality.
But, for others, the use of positive airway pressure can worsen insomnia, especially for those with co-morbid post-traumatic stress disorder (PTSD). And, for those with heart failure, the use of this sleep equipment can lead to central sleep apnea development, which is linked with insomnia, too.
The Bottom Line
Both insomnia and obstructive sleep apnea are common sleep disorders. In most cases, they require professional medical treatment. However, when it comes to medications, physicians and patients should always go for those with low toxicity, addictive potential, and minimal daytime sleepiness.